- Headache, vomiting, diarrhea. The document prepared by the Scientific Committee on Food describes a number of potential adverse effects following calcium supplementation. These findings were not accompanied by any microscopic changes in the lungs; histopathology did not reveal any treatment-related changes in the respiratory tract (or in any other tissues). findings at the high concentration level were considered to be of no toxicological relevance and were judged as non-adverse. Therefore, a classification as STOT RE is not justified and no classification is proposed. I-Acute Exposure A-Inhalation Ingestion Calcium carbonate is practically non-toxic by ingestion. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). Calcium Carbonate - Precipitated Section 1: Identification of the substance/mixture and of the company / undertaking 1.1 Product Identifier Product Name Calcium Carbonate - Precipitated Other Names Precipitated CAS No. GENERAL INFORMATION: Description : An inorganic substance mainly used as animal repellent but which also has herbicide, fungicide and/or microbiocide activity. These changes were largely, but not fully, reversible within a 4 week recovery period after the last exposure. effects on kidney function, milk-alkali syndrome, kidney stones and interactions with minerals. Acute Toxicity: Ground Calcium Carbonate Not classified Acute Toxicity: Crystalline Silica Oral, rat: LD 50 = 22,500 mg/kg LC 50 carp >10,000 mg/L/72 hr IARC: Group 1 Carcinogenic to humans Inhalation of respirable silica dust may not cause noticeable injury or illness even though permanent lung damage may be occurring. The local effects observed at this level were limited to increased lung weights accompanied by increases in BAL‑derived inflammation and cytotoxicity biomarkers, which were reversible in males but were not fully reversible in females within a 4-week recovery period. Calcium carbonate is a chemical compound with the formula Ca CO 3. via drinking water on a day to day basis. However, this effect is not demonstrable in long-term observational and interventional studies at dietary calcium intakes in the range of recommended intakes and at supplemental calcium of up to 2000 mg/day in adults and up to 1200 mg/day in one study with infants. Ingestion: Non-toxic. Scanning electron microscopy of aerosol samples confirmed that the particles were primarily present in agglomerates, which varied in size (ranging 60 nm – 30 µm, with trace amounts of primary particles) and shape, with little to no difference between the groups. 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant). Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. The NOAEL was therefore reported to be 1300 mg/kg bw/day. sur la façon dont nous utilisons les cookies. 1. Calcium carbonate is also a food additive approved by the Council Directive 95/2/EC on food additives (the substance has the acronym E 170). 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 09/11/2012 Revision date: 05/18/2015 Supersedes: 09/11/2012 Version: 2.0 05/18/2015 EN (English US) Page 1 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Calcium supplements that contain calcium citrate and calcium carbonate are not very efficient and, by some estimates, only 1-2% of the calcium in these forms will ever even reach your bones. Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Diagnosis is primarily clinical, but for some poisonings, blood and urine tests can help. A transient decrease in growth (females) or food consumption (males), observed in the top concentration group shortly after the initiation of exposure, was no longer observed after a few weeks. Vnitr Lek. Special Remarks on Toxicity to Animals: Not available. These findings were not substantiated by any concomitant changes in lung weight or treatment-related histopathology. Immediate reversal of digoxin toxicity with digoxin antibody (Fab) fragments will rapidly reduce the serum potassium and is the treatment of choice. Calcium carbonate is not very poisonous. The results of these studies are read across to bulk calcium carbonate. This article is for information only. The circumstances leading to the incident included the method of application of the fertiliser, low rainfall and the absence of subsequent irrigation of the fertilised pastures. Milk-alkali syndrome: Manifestation of the milk-alkali syndrome through the combined intake of calcium both from food and especially from supplements and of absorbable alkalinising substances is facilitated by renal insufficiency, alkalosis and dehydration due to vomiting and anorexia and/or the use of thiazide diuretics, which increase renal tubular calcium reabsorption. Calcium Carbonate ignites on contact with FLUORINE. Haematology and blood chemistry were evaluated prior to termination on five selected males and females from each dose group. In the body it is converted to calcium carbonate and cyanide, the latter inhibiting certain catalytic and oxidation-reduction processes, especially the cysteine-glutathione system. Route/Organism Dose Effect Reference; intravenous/rat : lowest published toxic dose: 30 mg/kg: Vascular: BP lowering not characterized in … If skin irritation persists, seek medical attention. Calcium salts (calcium carbonate, calcium chloride, and calcium magnesium acetate): Calcium salts are the most hazardous as they are the most severe irritants of all the ingredients in ice melts. Therefore, the findings at the high concentration level were considered to be of no toxicological relevance and were judged as non-adverse. Ammonia water (ammonium hydroxide [NH44OH]) See Caustic Ingestion — Ammoniated mercury (NH2HgCl) See Caustic Ingestion — Ammonium carbonate ([NH4]2CO3) See Caustic Ingestion — Ammonium fluoride (NH4F) See Fluorides — Amobarbital. This website uses cookies to ensure you get the best experience on our websites. Animals of the main groups were sacrificed on the day after the last exposure. It has a strong chlorine odor, but odor may not provide an adequate warning of hazardous concentrations. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The results of this study are read across to bulk calcium carbonate. The European Commission Scientific Committee on Food has produced a report on the Tolerable Upper Intake Level of Calcium (2003). Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution. CALCIUM CARBONATE (NATURAL) Version: 1.1/EN Revision date: May 2014 Printing Date: May 2014 Page 1 of 21 PRODUCT SAFETY DATA SHEET Prepared in accordance with Annex II of the REACH Regulation EC 1907/2006, 010 1. Dehydration, other medications, and other conditions including kidney problems, can … In conclusion, on the basis of the available evidence, a calcium dose which by itself might cause milk-alkali syndrome cannot be identified. Slightly harmful by inhalation. If ingested in large quantities, may cause nausea, constipation and hypercalcemia, hemorrhage. [1] BAL measurements are usually a rather sensitive toxicological read-out parameter, and it is not uncommon to observe treatment-related changes at concentrations below a level at which histopathology is induced. No indications for systemic toxicity of inhaled calcium carbonate (nano) were observed in this study. Since exposure to the test material did not induce any systemic toxicity, the NOEC for systemic effects was 0.399 mg/L. [Calcium carbonate poisoning]. 1 Material Safety Data Sheets Calcium Carbonate • Looe in te Lab • Loose in the Lab, Inc. Issue Date 6/11/2015 9462 South 560 West ... of inhalation. Calcium Carbonate Toxicology Identification and Uses. DO NOT use it to treat or manage an actual poison exposure. Calcium carbonate has a low toxicity and is not expected to cause serious health impact but may cause skin and eye irritation. Effects are only seen when this dose is significantly exceeded. Given the convergence of changes in pulmonary toxicological endpoints at the top concentration level – increased lung weights accompanied by increases in BAL‑derived inflammation and cytotoxicity biomarkers, which (in females) were not fully reversible within a 4-week recovery period – exposure to 0.399 mg/L calcium carbonate (nano) was considered to have resulted in an adverse response in the lower airways. Immediately with plenty of water and acids most prevalent minerals within the human body, calcium is largely retained the... Be a Health hazard from skin exposure carbonate is commonly found in many households inflammation cytotoxicity! Irritation and increased lung weight or treatment-related histopathology have been assigned a number! Animals were subjected to a newer version has herbicide, fungicide and/or microbiocide activity is contact a! Best experience on our websites with water and acids high concentration level were considered to be appropriate for inhalation! 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